Saved by Science

July 1, 2020
A survey of the new field of synthetic biology, "the science of building simple organisms or 'biological apps' to make manufacturing greener, energy production more sustainable, agriculture more robust and medicine more powerful and precise." In this energetic and optimistic book, Poznansky, former CEO of the Ontario Genomics Institute, shows how synthetic biology can be used to contend with major issues involving health, food, and the environment. This combination of engineering and molecular biology serves to design and build synthetic gene circuits and biomolecular components to reprogram organisms. The products are new life-forms, whether completely novel or partly modified. Examples include viruses that target specific diseased cells, genetically modified cells that remove heavy metals from lakes and rivers, and bacterium that take carbon out of the atmosphere. In layman's terms, Poznansky explains this new world of unnatural selection and nonrandom mutation, evolution by human design. Although he is profoundly enthusiastic about the prospects of genomics technologies and engineering, he recognizes that we are at the beginning of a process that requires the safest and most appropriate approaches: genetic manipulation incorporating safety switches to ensure containment, further understanding of gene editing, insertion, and expression, and the avoidance of the new gene being identified as a foreign substance. With sensible language and peer-reviewed research, the author explores the present and coming needs regarding global health care, food security, and pollution and examines the history of genetically modified organisms. Of special concern are the roles of ethics and regulation regarding safety, public interest, risk vs. reward, and the potential detrimental interference of political skulduggery, special-interest groups, and large corporations. Poznansky also takes to task anti-vaxxers and those that doubt the severity of climate change, while lauding the grassroots efforts--"the democratization of science"--that have already shown some promising results. Encouraging advances in biology delineated through accessible, inviting writing.

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